Socs1-derived peptide for use in chronic complications of diabetes

An isolated polynucleotide encoding

• a) the amino acid sequence SEQ ID NO 2;
• or
• b) a variant of the sequence of a) which is at least 85% identical to the sequence SEQ ID NO 2, based on the identity of all the nucleotides of said sequence;
• for use in the prevention or treatment of chronic complications of diabetes and/or neurodegenerative diseases of the retina, where chronic complications of diabetes are selected from the group consisting of diabetic retinopathy, macular edema, diabetic nephropathy, diabetic angiopathies, diabetic microangiopathies, diabetic macroangiopathies, diabetic atherosclerosis, diabetic foot and peripheral artery disease, and where neurodegenerative diseases of the retina are selected from the group consisting of diabetic retinopathy, glaucoma and retinitis pigmentosa.

An isolated polynucleotide encoding

• a) the amino acid sequence SEQ ID NO 2 bound to a lysine group;
• or
• b) a variant of the sequence of a) which is at least 85% identical to the sequence SEQ ID NO 2, bound to a lysine group, based on the identity of all the nucleotides of said sequence;
• for use in the prevention or treatment of chronic complications of diabetes and/or neurodegenerative diseases of the retina, where chronic complications of diabetes are selected from the group consisting of diabetic retinopathy, macular edema, diabetic nephropathy, diabetic angiopathies, diabetic microangiopathies, diabetic macroangiopathies, diabetic atherosclerosis, diabetic foot and peripheral artery disease, and where neurodegenerative diseases of the retina are selected from the group consisting of diabetic retinopathy, glaucoma and retinitis pigmentosa.