Methods and devices for activating adipose tissue
AssigneeThe Procter & Gamble Company
InventorsJose Mauro Goulart BRUM, Nicholas William GEARY, John Christian HAUGHT, Bhavani KASIBHATLA, Leo Timothy LAUGHLIN, II, Koti Tatachar SREEKRISHNA, John August WOS, Kenneth Edward YELM
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Abstract
Treatment for excess adipose tissue by applying an activating compound directly to a targeted area. The activating compound is a cyclohexanecarboxamide derivative. The activating compound promotes thermogenesis in cells to generate heat.
Claims20
A method of promoting thermogenesis comprising contacting one or more adipocytes with an activating compound, wherein the activating compound comprises the following structure or salts thereof:
- R1 is selected from H, alkyl, amino alkyl, alkoxy;
- Q=H2, O, —OR1, —N(R1)2, —OPO(OR1)x, —PO(OR1)x, —P(OR1)x where x=1-2;
- V=NR1, O, —OPO(OR1)x, —PO(OR1)x, —P(OR1)x where x=1-2;
- W=H2, O;
- X, Y=independently selected from H, aryl, naphthyl for n=0;
- X, Y=aliphatic CH2 or aromatic CH for n≥1 and Z is selected from aliphatic CH2, aromatic CH, or heteroatom;
- A=lower alkoxy, lower alkylthio, aryl, substituted aryl or fused aryl;
- and
- stereochemistry is variable at the positions marked*.
A method of treatment comprising contacting one or more adipocytes with an activating compound, wherein the activating compound comprises the following structure or salts thereof:
- R1 is selected from H, alkyl, amino alkyl, alkoxy;
- Q=H2, O, —OR1, —N(R1)2, —OPO(OR1)x, —PO(OR1)x, —P(OR1)x where x=1-2;
- V=NR1, O, —OPO(OR1)x, —PO(OR1)x, —P(OR1)x where x=1-2;
- W=H2, O;
- X, Y=independently selected from H, aryl, naphthyl for n=0;
- X, Y=aliphatic CH2 or aromatic CH for n≥1 and Z is selected from aliphatic CH2, aromatic CH, or heteroatom;
- A=lower alkoxy, lower alkylthio, aryl, substituted aryl or fused aryl;
- and
- stereochemistry is variable at the positions marked*.
A device comprising
- a therapeutically effective amount of an activating compound and
- a means for contacting one or more adipocytes with the activating compound.
Dependencies are inferred from the claim text.