Methods of identification and use of nematicide compounds
AssigneeUniversity of New Hampshire
InventorsRichard H. Cote, Karyn B. Cahill, Kevin D. Schuster
Life of this patent
Estimating the term…
Abstract
The invention relates, in part, to methods to identify compounds to treat a phytoparasitic nematode infection and/or reduce phytoparasitic nematode contamination, and to methods and compositions to treat phytoparasitic nematode infections and to reduce phytoparasitic nematode contamination of a substrate such as, but not limited to: a plant, agricultural medium, or soil.
Claims8
A method of identifying a candidate phytoparasitic nematode phosphodiesterase (PDE) inhibitor compound that disrupts cyclic nucleotide metabolism in a phytoparasitic nematode, the method comprising:
- a) contacting a phytoparasitic nematode test sample with a test compound under conditions suitable for PDE activity;
- b) measuring the level of PDE activity in the test sample;
- c) comparing the measured level of PDE activity in the test sample to a control level of PDE activity;
- and
- d) determining whether the contacted test sample has a reduced level of PDE activity relative to the control level of PDE activity, wherein a reduced level of PDE activity in the test sample relative to the control level of PDE activity identifies the test compound as a candidate phytoparasitic nematode PDE inhibitor compound that disrupts cyclic nucleotide metabolism in the phytoparasitic nematode.
6-10. (canceled)
12-56. (canceled)
Dependencies are inferred from the claim text.