Human rotavirus strains and vaccines
AssigneeThe U.S.A., as represented by the Secretary, Department of Health and Human Services
InventorsBaoming Jiang, Roger I. Glass, Yuhuan Wang, Jon Gentsch
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Abstract
A vaccine composition and method of vaccination are provided useful for immunizing a subject against a rotavirus. The vaccines include rotavirus strains CDC-9 and CDC-66, fragments thereof, homologues thereof, or combinations thereof. Inventive vaccines may include a fragment of CDC-9, CDC-66, homologues thereof, or combinations thereof. Methods of inducing an immunological response are provided by administering an inventive vaccine.
Claims13
An isolated rotavirus non-structural protein (NSP) protein, wherein
- a) the NSP protein is a NSP1 protein that has greater than 95% identity to SEQ ID NO:
- 3, and wherein amino acid 122 is an arginine;
- b) the NSP protein is a NSP5 protein that i) has greater than 95% identity to SEQ ID NO:
- 15, and wherein amino acid 45 is an isoleucine, or ii) has greater than 95% identity to SEQ ID NO:
- 96, and wherein amino acid 60 is a valine;
- or
- c) the NSP protein is a NSP2 protein that has greater than 95% identity to SEQ ID NO:
- 78, and wherein amino acid 142 is a tyrosine.
The isolated rotavirus NSP protein of claim 5, wherein the NSP5 protein consists of the amino acid sequence of SEQ ID NO:
- 15 or SEQ ID NO:
- 96.
Dependencies are inferred from the claim text.