In a digital medium environment for providing digital layouts to client devices across computer networks, a method for generating enhanced digital layouts uniquely tailored to particular audiences, comprising:
- identifying digital content fragments, performance metrics associated with the digital content fragments, and a distribution audience;
- performing a step for iteratively mutating layout chromosomes based on the performance metrics to generate a final layout chromosome comprising a ranking of a subset of digital content fragments;
- and
- performing a step for generating a digital layout based on the ranking of the subset of digital content fragments in the layout chromosome and region importance metrics of regions within the digital layout.