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US 2020/0003790 A1Published application
Synthetic blood vessels and uses thereof
AssigneeThe University of British Columbia
InventorsCHERYL WELLINGTON, JEROME ROBERT
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Abstract
The present invention provides a synthetic blood vessel and use thereof in drug screening, drug delivery and prognoses of cerebrovascular dysfunction.
Claims21
A method of identifying an amyloid beta (Aβ) modulator, the method comprising:
- i) providing a synthetic blood vessel,
- ii) providing an Aβ peptide;
- iii) providing a test compound;
- iv) contacting the synthetic blood vessel with the Aβ peptide;
- v) contacting the synthetic blood vessel with the test compound;
- and
- vi) determining the level of Aβ deposition or transport,
- wherein the test compound is an Aβ modulator if it inhibits Aβ deposition or enhances Aβ transport.
5 more elements
-18. (canceled)
A method of determining whether a compound is suitable for delivery to the brain, comprising:
- i) providing a synthetic blood vessel, wherein the synthetic blood vessel is at least a tripartite vessel;
- i) contacting the lumen of the synthetic blood vessel with a test compound;
- ii) determining the level of transport of the test compound to the antelumen of the tripartite vessel,
- wherein the test compound is suitable for delivery to the brain if it is transported to the antelumen of the tripartite vessel.
1 more element
A synthetic blood vessel kit comprising:
- i) a synthetic blood vessel;
- and
- ii) an amyloid beta (Aβ) peptide, together with instructions for use, wherein the synthetic blood vessel kit optionally further comprises a lipoprotein or a monocytic cell or a combination thereof.
Dependencies are inferred from the claim text.