Fecal bacterial markers for colorectal cancer
AssigneeThe Chinese University of Hong Kong
InventorsJun YU, Joseph Jao Yiu Sung, Qiaoyi Liang
Life of this patent
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Abstract
Provided is a non-invasive method for diagnosing colorectal cancer in a subject by detecting enrichment or reduction of certain bacterial species. A kit and device useful for such methods are also provided. In addition, a method for reducing the risk of colon cancer by regulating the pertinent bacterial species in human colon is also provided.
Claims27
A method for assessing risk for colon cancer in a subject, comprising the steps of:
- (a) quantitatively determining level of at least one of Parvimonas micra, Solobacterium moorei, Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi in a stool sample taken from the subject;
- (b) comparing the level obtained in step (a) with a standard control;
- (c) determining the level obtained in step (a) as increased or decreased from the standard control;
- and
- (d) determining the subject as having an increased risk for colon cancer.
-14. (canceled)
A kit for detecting colon cancer in a subject, comprising (1) a standard control that provides an average amount of at least one of Parvimonas micra, Solobacterium moorei, Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi in a stool sample;
- and (2) an agent that specifically and quantitatively identifies a DNA, RNA, or protein unique to at least one of Parvimonas micra, Solobacterium moorei, Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi.
-20. (canceled)
A method for reducing the risk of developing colon cancer cell in a subject, comprising administering to the subject an effective amount of an inhibitor or enhancer for at least one of Parvimonas micra, Solobacterium moorei, Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi.
(canceled)
A method for assessing risk for colon cancer in a subject, comprising the steps of:
- (a) quantitatively determining level of at least one of Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi in a stool sample taken from the subject;
- (b) comparing the level obtained in step (a) with a standard control;
- (c) determining the level obtained in step (a) as increased or decreased from the standard control;
- and
- (d) determining the subject as having an increased risk for colon cancer.
-35. (canceled)
A kit for detecting colon cancer in a subject, comprising (1) a standard control that provides an average amount of at least one of Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi in a stool sample;
- and (2) an agent that specifically and quantitatively identifies a DNA, RNA, or protein unique to at least one of Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi.
-45. (canceled)
A method for reducing the risk of developing colon cancer cell in a subject, comprising administering to the subject an effective amount of an inhibitor or enhancer for at least one of Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi.
(canceled)
A method for detecting increased or decreased level of at least one of Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi in a stool sample, comprising the steps of:
- (a) quantitatively determining level of at least one of Bacteroides clarus, Roseburia intestinalis, and Clostridium hathewayi in the stool sample;
- (b) comparing the level obtained in step (a) with a standard control;
- and
- (c) determining the level obtained in step (a) as increased or decreased from the standard control.
-58. (canceled)
Dependencies are inferred from the claim text.