Reversibly protected triazabutadienes
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsJohn C. Jewett, Lindsay E. Guzman, Bereketab T. Mehari, Jie He
Life of this patent
Estimating the term…
Abstract
Triazabutadiene molecules and methods of use of triazabutadiene molecules, for example methods and compositions for yielding an aryl diazonium species from a triazabutadiene molecule, e.g., a protected aryl diazonium species in the form of a triazabutadiene. In some embodiments, an enzyme catalyzes the reaction yielding the aryl diazonium species from the triazabutadiene molecule. As an example, the methods and compositions herein may be used for delivery of drugs.
Claims20
A compound of Formula B:
- wherein:
- A is —N—;
- D is —H;
- E is —H;
- X1 is an aryl, an alkyl, a carboxylic acid, an alcohol, or an amine;
- Y1 is an aryl, an alkyl, a carboxylic acid, an alcohol, or an amine;
- Z1 is an aryl;
- and
- Z2 is a moiety comprising a carbonyl group;
- wherein the compound releases a triazabutadiene molecule and a derivative of Z2 when subjected to a trigger that results in deprotection of N1 nitrogen.
A method of selectively activating a triazabutadiene, said method comprising introducing a trigger to a compound according to Formula B:
- wherein:
- A is —N—;
- D is —H;
- E is —H;
- X1 is an aryl, an alkyl, a carboxylic acid, an alcohol, or an amine;
- Y1 is an aryl, an alkyl, a carboxylic acid, an alcohol, or an amine;
- Z1 is an aryl;
- and
- Z2 is a moiety comprising a carbonyl group;
- wherein the trigger results in deprotection of N1 nitrogen to cause the compound to yield an active triazabutadiene molecule and a derivative of Z2.
Dependencies are inferred from the claim text.