System and method for geometrically-resolved radiographic x-ray imaging

A system for determining a biophysical model for a lung of a patient from multiple x-ray measurements corresponding to different breathing phases of the lung, comprising:

• one or more processors;
• and
• memory storing instructions which, when executed by the one or more processors, cause the one or more processors to perform a set of operations, including:
• converting first multiple sets of x-ray images of a lung captured at different projection angles into second multiple sets of x-ray images of the lung corresponding to different breathing phases;
• generating a static image cube from each set of the second multiple sets of x-ray images at a respective breathing phase using back projection;
• and
• combining the static image cubes corresponding to the different breathing phases of the lung into a 3D x-ray image cube movie through temporal interpolation.

A non-transitory computer-readable storage medium storing instructions, which, when executed by a system that includes one or more processors, cause the one or more processors to perform a set of operations, including:

• converting first multiple sets of x-ray images of a lung captured at different projection angles into second multiple sets of x-ray images of the lung corresponding to different breathing phases;
• generating a static image cube from each set of the second multiple sets of x-ray images at a respective breathing phase using back projection;
• and
• combining the static image cubes corresponding to the different breathing phases of the lung into a 3D x-ray image cube movie through temporal interpolation.