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US 2019/0376986 A1Published application
In Vitro Diagnosis Device and Uses Thereof
AssigneeDiagast
InventorsNajim Chaibi, Sylvain Malgouries, Megumi Lucas
Life of this patent
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AssigneeDiagast
InventorsNajim Chaibi, Sylvain Malgouries, Megumi Lucas
Estimating the term…
The invention relates to an in vitro diagnosis device for the detection of at least one reaction between an erythrocytic phenotype antigen and an antibody specifically directed against said antigen in a sample of blood or one of the components thereof. The device is characterized in that it comprises: a substrate; and a hydrophobic porous membrane having a thickness of between 0.5 mm and 1.5 mm and a pore diameter of between 2 and 30 μm, said membrane comprising at least one hydrophilic reaction zone intended to receive the sample. The invention also relates to the uses of said device in immunohematology.
An in-vitro diagnosis device (10), for detection of at least one reaction between an antigen of erythrocytic phenotype and an antibody directed specifically against this antigen, from a sample of blood or one of its components, characterized in that it comprises:
The diagnosis device (10) according to any one of the preceding claims, characterized in that the porous membrane (14) is arranged in the support (12) and in that the support (12) comprises at least one opening (20), each opening (20) being at right angle of each hydrophilic reaction area (16) of the porous membrane.
The diagnosis device (10) according to any one of the preceding claims, characterized in that the support (12) is a rigid plastic support.
The diagnosis device (10) according to any one of the preceding claims, characterized in that it also comprises an absorbent membrane (18) arranged underneath the porous membrane (14).
The diagnosis device (10) according to any one of the preceding claims, characterized in that the hydrophilic reaction area (16) of the porous membrane (14) also comprises capturing agents.
The diagnosis device (10) according to any one of the preceding claims, characterized in that the capturing agents comprise antigens of erythrocytic group/phenotype.
The diagnosis device (10) according to any one of the preceding claims, characterized in that the reaction area (16) is hydrophilic over the entire thickness of the porous membrane.
The diagnosis device (10) according to any one of the preceding claims, characterized in that the reaction area (16) is hydrophilic at the surface of said reaction area.
The diagnosis device (10) according to any one of the preceding claims, characterized in that the reaction area (16) comprises two hydrophilic areas (16-1, 16-2) with a greater degree of hydrophilisation at the centre (16-1) of the reaction area than at the periphery (16-2).
A manufacturing process of a device (10) according to any one of the preceding claims, characterized in that it comprises the following steps:
Dependencies are inferred from the claim text.