Diagnostic for lung disorders using class prediction

A method of diagnosing a lung disease in an individual exposed to air pollutant comprising the steps of

• a) measuring expression profile of a gene group in the sample from a test individual;
• and
• b) comparing the expression profile of the test individual to an expression profile of a first control individual exposed to similar air pollutant who does not have the lung disease and the expression profile of a second control individual exposed to similar air pollutants who has the lung disease,
• wherein similarity of the expression profile of the test individual with the expression profile of the first control rather than that of the second control is indicative of the test individual being not affected with the lung disease and wherein similarity of the expression profile of the test individual with the expression profile of the second control individual rather than that of the first control individual is indicative of the test individual being affected or at high risk of developing the lung disease.