Compositions and methods targeting the th2 pathway for the treatment of asthma

A method for treating an asthma comprising;

• a) obtaining a biological sample comprising nucleic acids from a human subject, or obtaining genetic information from a human subject;
• and
• b) detecting in said sample, or identifying in said genetic information, the presence or absence of nucleic acids harboring a combination of single nucleotide polymorphisms (SNPs) selected from 1) rs2786098 and rs2014202, or 2) rs2786098 and rs7522056;
• and
• c) administering an agent that targets the Th2 inflammation pathway when said combination is detected.

A method for treating asthma and/or treating a Th2 high molecular phenotype asthma in a human subject, comprising,

• a) obtaining a biological sample comprising nucleic acids from a human subject, or obtaining genetic information relating to the subject;
• b) detecting in the sample, or determining from the genetic information whether the subject has:
• i) any one or more of SNPs rs2014202, rs7522056, rs6673687, rs11240565, rs11240554, rs823116, rs1775146, rs1775143, rs12565321, and rs12567894;
• or
• ii) rs2786098 together with any one or more of SNPs:
• rs2014202, rs7522056, rs6673687, rs11240565, rs11240554, rs823116, rs1775146, rs1775143, rs12565321, and rs12567894;
• and
• c) administering an effective amount of an agent that targets the Th2 inflammation pathway such as any one or more of the agents of Table 2 to the subject in subjects where i) or ii) are present subject, thereby treating asthma.