Collagen-binding agent compositions and methods of using the same
AssigneesBoard of Trustees of the University of Arkansas, The Kitasato Institute
InventorsJoshua SAKON, Jeffrey ROESER, Ryan BAUER, Katarzyna JANOWSKA, Keisuke TANAKA, Osamu MATSUSHITA, Kentaro UCHIDA
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Abstract
The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.
Claims20
A collagen-binding therapeutic agent comprising two collagen-binding domains linked by a domain linker and a therapeutic agent linked to at least one of the collagen-binding domains by a therapeutic agent linker, wherein the collagen-binding agent lacks collagenase activity, and wherein each of the two collagen-binding domains are selected from the group consisting of any one of the polypeptides of SEQ ID NOs:
- 1-39, a polypeptide having at least 90% sequence identity to any one of SEQ ID NOs:
- 1-39, and a fragment of at least 8 consecutive amino acids of any one of SEQ ID NOs:
- 1-39,
(canceled)
Dependencies are inferred from the claim text.