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US 2019/0376050 A1Published application
Mirror nucleic acid replication system
AssigneeTsinghua University
InventorsTing ZHU, Lei LIU, Weiliang XU, Zimou WANG, Wenjun JIANG, Jiaxing WANG, Linping YU
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Abstract
Provided is a method for replicating a mirror nucleic acid, comprising: reacting a mirror nucleic acid template, a mirror nucleic acid primer and mirror dNTPs/rNTPs in the presence of a mirror nucleic acid polymerase, so as to obtain the mirror nucleic acid.
Claims26
A method for replicating a mirror-image nucleic acid, comprising:
- carrying out a reaction in the presence of a mirror-image nucleic acid polymerase, a mirror-image nucleic acid template, a mirror-image nucleic acid primer, and mirror-image dNTPs/rNTPs to obtain the mirror-image nucleic acid.
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-19. (canceled)
A method for screening a mirror-image nucleic acid molecule, comprising:
- contacting a library of random mirror-image nucleic acid sequences with a target molecule under a condition that allows binding of the two;
- obtaining a mirror-image nucleic acid molecule that binds to the target molecule;
- and
- amplifying the mirror-image nucleic acid molecule that binds to the target molecule by mirror-image PCR.
1 more element
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D-ASFV pol X, the sequence of which is set forth in SEQ ID NO:
- 17, wherein except for glycine which is not chiral, all other amino acids are D-form amino acids.
Dependencies are inferred from the claim text.