Modified Natural Killer Cells And Uses Thereof
AssigneesNational University of Singapore, St. Jude Children's Research Hospital
InventorsDario Campana, David Shook, Masaru Imamura
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Abstract
The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.
Claims13
A method of producing a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), comprising:
- a) introducing nucleic acid encoding all or a functional portion of IL-15 into the NK cell;
- and
- b) maintaining the NK cell under conditions in which all or a functional portion of the IL-15 is expressed,
- thereby producing a NK cell that expresses all or a functional portion of IL-15.
A method of treating cancer in an individual in need thereof comprising administering to the individual a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15).
A method of enhancing expansion and/or survival of NK cells, comprising:
- a) introducing nucleic acid encoding all or a functional portion of IL-15;
- and
- b) maintaining the NK cells under conditions in which all or a functional portion of the IL-15 is expressed and the NK cells proliferate,
- thereby enhancing expansion and/or survival of the NK cells.
Dependencies are inferred from the claim text.