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US 2019/0376031 A1Published application
Compositions and methods for in vitro cultivation and/or expansion of regulatory t cells
AssigneeEast Carolina University
InventorsDaniel Stephen WILKINSON, Mark D. MANNIE
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Abstract
FOXP3+ regulatory T cells (Tregs) can represent powerful adoptive immunotherapies for autoimmune diseases, metabolic diseases, and other chronic inflammatory diseases. The present invention is related to the ability to maintain and expand stable Treg lines and can provide insight into FOXP3+ Treg physiology and can enable feasible strategies of Treg-based immunotherapy.
Claims31
A method of preparing a regulatory T-cell (Treg) population comprising:
- exposing T-cells to a medium comprising an anti-inflammatory cytokine and an anti-inflammatory cytokine receptor inhibitor;
- and
- propagating the T-cells in the medium comprising the anti-inflammatory cytokine and the anti-inflammatory cytokine receptor inhibitor to provide a Treg population.
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Dependencies are inferred from the claim text.