Regulatory t cell populations
AssigneeMemorial Sloan Kettering Cancer Center
InventorsAlexander Y. Rudensky, Andrew G. Levine
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Abstract
The present disclosure provides regulatory T cells and regulatory T cell populations engineered to express a transcription factor. The present disclosure provides for treatment of immune disorders with regulatory T cells and regulatory T cell populations engineered to express a transcription factor.
Claims26
An isolated population of regulatory T (Treg) cells which have been engineered to express Tbet.
A method of suppressing a TH1 type immune response the method comprising administering to a subject a population of Tregs which have been engineered to express Tbet.
A method of preparing an specialized Treg population, the method comprising:
- obtaining an initial Treg cell or population
- culturing the initial Treg cell or population for a period of time and under conditions sufficient that a specialized Treg population characterized in that Tbet expression is increased 2, 5, 10, 20, 30, 40, 50, 60 fold relative to a reference is prepared.
Dependencies are inferred from the claim text.