ANTI-HtrA1 ANTIBODIES AND METHODS OF USE THEREOF

An isolated antibody that specifically binds HtrA1, wherein the antibody comprises a binding domain comprising at least one of the following six HVRs:

• (a) an HVR-H1 comprising the amino acid sequence of SYIMS (SEQ ID NO:
• 39);
• (b) an HVR-H2 comprising the amino acid sequence of YISNGGGTTYYSDTIKG (SEQ ID NO:
• 40);
• (c) an HVR-H3 comprising the amino acid sequence of QNFRSDGSSMDY (SEQ ID NO:
• 41);
• (d) an HVR-L1 comprising the amino acid sequence of RASESVDSYGKSFMH (SEQ ID NO:
• 42);
• (e) an HVR-L2 comprising the amino acid sequence of LASKLES (SEQ ID NO:
• 43);
• and
• (I) an HVR-L3 comprising the amino acid sequence of QQNNEDPYT (SEQ ID NO:
• 44).