Monoclonal Antibody Which Specifically Recognizes B Cell Lymphoma and Use Thereof

A method for treating B cell lymphoma, the method comprising administering a pharmaceutically effective amount of composition, the composition comprising a monoclonal antibody specific to B cell lymphoma to a subject, the monoclonal antibody comprising:

• a heavy chain variable region comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
• 2;
• a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
• 3;
• and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
• 4;
• and
• a light chain variable region comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
• 6;
• a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
• 7;
• and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
• 8.

A method of providing information for diagnosing B cell lymphoma, the method comprising:

• (a) treating, with a monoclonal antibody, a separated biological sample from a subject suspected of having B cell lymphoma;
• and
• (b) detecting the presence of B cell lymphoma cells from the sample in step (a),
• wherein the monoclonal antibody comprises a heavy chain variable region comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
• 2;
• a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
• 3;
• and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
• 4;
• and a light chain variable region comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
• 6;
• a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
• 7;
• and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
• 8.