Binding agents
AssigneeUltrahuman Four Limited
InventorWilliam James Jonathan Finlay
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Abstract
The invention relates to antibody molecules and antigen-binding portions thereof which bind specifically to CD47 (Cluster of Differentiation 47, also known as integrin associated protein [IAP]). In aspects of the invention, the anti-CD47 antibody molecules and antigen-binding portions thereof specifically bind to human CD47 and cynomolgus monkey CD47. Medical uses of the anti-CD47 antibody molecules and antigen-binding portions of the invention are disclosed. The anti-CD47 antibody molecules and antigen-binding portions of the invention represent modified and optimised binding molecules compared with a VxP037 murine/humanized anti-CD47 antibody described in WO2014/093678A2.
Claims23
An antibody molecule that specifically binds to human Integrin Associated Protein (CD47) and cynomolgus monkey CD47, or an antigen-binding portion thereof, wherein the antibody molecule or antigen-binding portion comprises:
- (a) a heavy chain variable region comprising a heavy chain complementarity determining region (HCDR) 1 of SEQ ID NO:
- 49, a HCDR2 of SEQ ID NO:
- 50, and a HDCR3 of SEQ ID NO:
- 51;
- and a light chain variable region comprising a light chain complementarity determining region (LCDR) 1 of SEQ ID NO:
- 52, a LCDR2 of SEQ ID NO:
- 53, and a LDCR3 of SEQ ID NO:
- 54;
- or
- (b) a heavy chain variable region comprising a HCDR1 of SEQ ID NO:
- 49, a HCDR2 of SEQ ID NO:
- 50, and a HDCR3 of SEQ ID NO:
- 51;
- and a light chain variable region comprising a LCDR1 of SEQ ID NO:
- 52, a LCDR2 of SEQ ID NO:
- 85, and a LDCR3 of SEQ ID NO:
- 54.
-6. (canceled)
(canceled)
-17. (canceled)
(canceled)
-34. (canceled)
Dependencies are inferred from the claim text.