Tim-3 antibody, antigen binding fragment thereof, and medicinal uses thereof

A TIM-3 antibody or antigen-binding fragment thereof which binds to an extracellular region of human TIM-3 antigen and is selected from any one of the monoclonal antibody or antigen-binding fragment thereof of the following (i) to (ii):

• (i) a monoclonal antibody or antigen-binding fragment thereof, comprising
• heavy chain variable region HCDR 1-3 sequences as shown in:
• SEQ ID NOs:
• 8, 43 and 10, respectively;
• and light chain variable region LCDR 1-3 sequences as shown in:
• SEQ ID NOs:
• 11, 12 and 13, respectively,
• wherein the SEQ ID NO:
• 43 is shown as DIIPX1X2X3GSKYNQKFKD,
• wherein X1 is N, L, V, M or E, X2 is N, E, M, H, K, L, A or V;
• and X3 is G or A;
• or
• (ii) a monoclonal antibody or antigen-binding fragment thereof, comprising
• heavy chain variable region HCDR 1-3 sequences as shown in:
• SEQ ID NOs:
• 14, 15 and 16 respectively;
• and light chain variable region LCDR 1-3 sequences as shown in:
• SEQ ID NOs:
• 17, 18 and 19, respectively,
• or a monoclonal antibody or antigen-binding fragment thereof that competes with the monoclonal antibody or antigen-binding fragment of (i) or (ii).