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US 2019/0375828 A1Published application
Antibodies that Neutralize Botulinum Neurotoxins
AssigneeThe Regents of the University of California
InventorsJames D. Marks, Jianlong Lou
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Abstract
This disclosure provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Claims25
1-45. (canceled)
A composition comprising:
- a) a first isolated nucleic acid comprising a nucleotide sequence encoding a variable heavy chain (VH) polypeptide comprising:
- a VH CDR1 comprising the amino acid sequence of NYPMS (SEQ ID NO:520),
- a VH CDR2 comprising the amino acid sequence of SLTASGDNTFYADSVKG (SEQ ID NO:522),
- a VH CDR3 comprising the amino acid sequence of ALVGRYDISTGYYRPVMDS (SEQ ID NO:524);
- and
- b) a second isolated nucleic acid comprising a nucleotide sequence encoding a variable light chain (VL) polypeptide comprising:
- a VL CDR1 comprising the amino acid sequence of RTSQGFTSALA (SEQ ID NO:770),
- a VL CDR2 comprising the amino acid sequence of DASKLES (SEQ ID NO:772), and
- a VL CDR3 comprising the amino acid sequence of QQSNSYPLT (SEQ ID NO:774).
6 more elements
A composition comprising:
- a) a first isolated nucleic acid comprising a nucleotide sequence encoding an amino acid sequence of a variable heavy chain (VH) polypeptide comprising an amino acid of SEQ ID NO:23;
- and
- b) a second isolated nucleic acid comprising a nucleotide sequence encoding an amino acid sequence of a variable light chain (VL) polypeptide comprising an amino acid sequence of SEQ ID NO:59.
Dependencies are inferred from the claim text.