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US 2019/0375825 A1Published application
Antibodies that potently neutralize rsv and uses thereof
AssigneeHumabs Biomed SA
InventorDavide Corti
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AssigneeHumabs Biomed SA
InventorDavide Corti
Estimating the term…
The invention relates to antibodies, and antigen binding fragments thereof, that neutralize infection of both group A and group B RSV. The invention also relates to antigenic sites to which the antibodies and antigen binding fragments bind, as well as to nucleic acids that encode and immortalized B cells and cultured plasma cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and polypeptides recognized by the antibodies of the invention in screening methods as well as in the diagnosis, treatment and prevention of RSV infection and group A and group B RSV co-infection.
-52. (canceled)
A recombinant host cell that expresses an antibody, or an antigen-binding fragment thereof, the antibody or antigen-binding fragment comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH and the VL comprise CDRH1, CDRH2, and CDRH3 amino acid sequences and CDRL1, CDRL2, and CDRL3 amino acid sequences as set forth in:
Dependencies are inferred from the claim text.