Methods of treating hemophilia a
AssigneeBioverativ Therapeutics Inc.
InventorsEkta SETH CHHABRA, Alison INNES, Dan RUDIN, Kara RICE, Nancy WONG, Suresh KATRAGADDA
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Abstract
The present disclosure provides a method of treating hemophilia A in a human subject in need thereof comprising administering to the subject a chimeric polypeptide comprising (i) a factor VIII (FVIII) protein and (ii) a von Willebrand factor (VWF) fragment comprising a D′ domain of VWF and a D3 domain of VWF at a dosing interval.
Claims21
1-89. (canceled)
A method of treating hemophilia A in a human subject comprising administering to the subject in need thereof multiple doses of a chimeric polypeptide at a dosing interval, wherein the chimeric polypeptide comprises:
- (i) a FVIII protein comprising the amino acid sequence of SEQ ID NO:
- 203;
- and
- (ii) a VWF protein comprising the amino acid sequence of SEQ ID NO:
- 205;
- wherein at least one of the multiple doses is from 15 IU/kg to 100 IU/kg and the dosing interval is at least 5 days.
A method of treating hemophilia A in a human subject comprising administering to the subject in need thereof multiple doses of a chimeric polypeptide at a dosing interval, wherein the chimeric polypeptide comprises:
- (i) a FVIII protein comprising:
- (a) a first FVIII polypeptide fragment comprising the amino acid sequence of SEQ ID NO:
- 215;
- (b) a first XTEN sequence comprising the amino acid sequence of SEQ ID NO:
- 8 (AE288);
- (c) a second FVIII polypeptide fragment comprising the amino acid sequence of SEQ ID NO:
- 216;
- and
- (d) a first Fc region comprising the amino acid sequence of SEQ ID NO:
- 217;
- (ii) a VWF protein comprising:
- (a) a D′ domain of VWF comprising the amino acid sequence of SEQ ID NO:
- 210;
- (b) a D3 domain of VWF comprising the amino acid sequence of SEQ ID NO:
- 214;
- (c) a second XTEN sequence comprising the amino acid sequence of SEQ ID NO:
- 58 (AE144_5A);
- (d) an a2 linker comprising the amino acid sequence of SEQ ID NO:
- 88;
- and
- (e) a second Fc region comprising the amino acid sequence of SEQ ID NO:
- 217;
- wherein the first Fc region is covalently linked to the second Fc region by a disulfide bond.
Dependencies are inferred from the claim text.