Method of treating breast cancer
AssigneesHudsonAlpha Institute for Biotechnology, The UAB Research Foundation
InventorsKatherine E VARLEY, Richard M MYERS, Brian S ROBERTS, Jason GERTZ, Donald J Buchsbaum, Andres Forero-Torres, Albert F LoBuglio
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Abstract
The present disclosure provides for and relates to novel fusion proteins and polypeptides expressed by breast cancer and other cancer cells, and to compositions, materials and methods for detecting, characterizing and treating said breast and other cancers. In one embodiment, the fusion polypeptides are read-through fusion transcripts.
Claims26
A method of treating breast cancer in a subject in need thereof, the method comprising:
- (a) detecting the expression of a fusion polypeptide in a sample from the subject, the fusion polypeptide having at least 90/o identity with one or more of SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6 and SEQ ID NO:
- 7;
- (b) diagnosing the subject with breast cancer when the expression of the fusion polypeptide is detected in the sample;
- and
- (c) administering an effective amount of a breast cancer therapy to the diagnosed subject.
A method of treating breast cancer in a subject who has been diagnosed with breast cancer, the method comprising:
- administering an effective amount of a breast cancer therapy to the diagnosed subject, wherein a fusion polypeptide has been detected in a sample from the subject, the fusion polypeptide having at least 90% identity with one or more of SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6 and SEQ ID NO:
- 7, and wherein the subject has been diagnosed with breast cancer when the expression of the fusion polypeptide is detected in the sample.
Dependencies are inferred from the claim text.