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US 2019/0375805 A1Published application
Naf-1 derived peptides and uses thereof
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsRachel NECHUSHTAI, Assaf FRIEDLER, Anat IOSUB-AMIR, Merav DARASH-YA-HANA, Yang-Sung SOHN, Dorit MICHAELI
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Abstract
The present invention provides peptides comprising a sequence derived from the human NAF-1 protein, analogs of said sequence or a retro-inverso sequence of said peptide or analog. The conjugates of such peptides are provided as well. The peptides and the conjugates of the present invention are useful in treating cancer, and in particular cancer in which the expression of NAF-1 is enhanced.
Claims21
1-37. (canceled)
A peptide comprising:
- (a) the amino acid sequence FLGVLALLGYLAVRPFLPKKKQQK set forth as SEQ ID NO:
- 1;
- (b) an analog of (a);
- (c) a retro-inverso sequence of (a) or (b);
- or
- (d) a fragment consisting of 17 to 23 consecutive amino acids of (a), (b) or (c);
- wherein the peptide consists of 17 to 50 amino acids.
4 more elements
Dependencies are inferred from the claim text.