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US 2019/0375790 A1Published application
Multi-target peptide molecules of opioid and neuropeptide ff receptor, preparation for molecules, and applications thereof
AssigneeShanghai Tianci Life Science Development Co., Ltd.
InventorsRui WANG, Quan FANG, Zilong WANG, Biao XU
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Abstract
Provided are nine multi-target polypeptides of an opioid and a neuropeptide FF receptor, where an amino acid is replaced on the basis of opioid peptide biphalin- and NPFF-based chimeric peptide BN-9, and acquired are the multi-target polypeptides capable of concurrently activating various opioid and NPFF system receptors.
Claims12
A multi-target polypeptide of opioid and neuropeptide FF receptors, having the
- Xaa1-D-Ala-Gly-Xaa2-Xaa3-Pro-Gln-Arg-Phe-NH2
- where Xaa1 is Tyr or NMe-Tyr, Xaa2 is Phe or NMe-Phe:
- Xaa3 is Gln, Gly, Leu, Met, D-Met, D-Leu or D-Ala,
Dependencies are inferred from the claim text.