Cyclic dinucleotides as sting agonists

A compound of Formula (I)

• wherein
• R is CH2 or O;
• R1B is hydrogen, hydroxy, or fluoro;
• R1C is selected from the group consisting of hydroxy, thiol, and BH3−;
• R2B is hydrogen, hydroxy, methoxy, or fluoro;
• R2C is selected from the group consisting of hydroxy, thiol, and BH3−;
• B1 is selected from the group consisting of rings b1, b2, b3, b4, b5, b6, b7 and b8
• W is —O— or —NH—;
• X is —O— or —NH—;
• Y is —CH2—, —O— or —NH—;
• Z is —CH2—, —O— or —NH—;
• such that only one of X and Y is NH, and only one of W and Z is NH, in any instance;
• and, such that when R is CH2 and B1 is selected from b6 or b7, then R2B is other than fluoro or hydroxy;
• furthermore, provided that a compound of Formula (I) is other than a compound wherein R, W, X, Y, and Z, are each O;
• R1B and R2B are each hydroxy;
• B1 is b1;
• and R1B and R2B are each hydroxy;
• or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.