Cyclic dinucleotides as sting agonists

A compound of Formula (I)

• wherein
• R1A, R2A, R1D, R2D, and R2E are each independently selected from hydrogen or methyl;
• such that one of said R1A, R2A, R1D, R2D, and R2E is methyl;
• R1B is hydrogen, hydroxy or fluoro;
• or, R1B is —O—, and R1D is CH2, wherein R1B, R1D and the atoms to which they are attached form a 5-membered ring;
• R1C is selected from the group consisting of hydroxy and thiol;
• B1 is ring b2
• R2B is selected from the group consisting of hydroxy, fluoro and methoxy;
• R2C is selected from the group consisting of hydroxy and thiol;
• or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.

A compound of Formula (II)

• wherein
• R1H is fluoro;
• or, R1H is —O—, and R1J is CH2, wherein R1H, R1J and the atoms to which they are attached form a 5-membered ring;
• R1J is hydrogen or methyl;
• R1K is selected from the group consisting of hydroxy or thiol;
• R2L is selected from the group consisting of hydroxy and thiol;
• or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.