Adenosine derivatives for use in the treatment of cancer
AssigneeNuCana plc
InventorsHugh Griffith, Michaela Serpi, Magadalena Slusarczyk, Christopher McGuigan
Life of this patent
Estimating the term…
Abstract
The present invention relates to chemical compounds of formula (I), their preparation, and their use in the treatment of cancer.
Claims27
A compound of formula I:
- wherein:
- each of R1 and R2 is independently selected from the group consisting of H, C1-8alkyl, benzyl, C2-8alkenyl, C1-4alkoxyC1-4alkyl, C2-8alkynyl, C3-8cycloalkyl, and 4-8heterocycloalkyl, any of which is optionally substituted;
- R3 is selected from the group consisting of H, C1-8alkyl, benzyl, C2-8alkenyl, C1-4alkoxyC1-4alkyl, C2-8alkynyl, C3-8cycloalkyl, 4-8heterocycloalkyl, phenyl, naphthyl, 5- or 6-membered monocyclic heteroaryl and 9- or 10 membered bicyclic heteroaryl, any of which is optionally substituted;
- R4 is selected from the group consisting of H, C1-8alkyl, benzyl, C2-8alkenyl, C1-4alkoxyC1-4alkyl, C2-8alkynyl, C3-8cycloalkyl, and 4-8heterocycloalkyl, any of which is optionally substituted;
- R5 is independently selected from OAr and
- and
- Ar is selected from the group consisting of phenyl, naphthyl, 5- or 6-membered monocyclic heteroaryl and 9- or 10 membered bicyclic heteroaryl, each of which is optionally substituted;
- or a pharmaceutically acceptable salt, ester, salt of an ester, solvate, prodrug or salt of a prodrug thereof.
(canceled)
The compound of 14, wherein the compound of formula (I) is
- (2S)-Benzyl 2-(((((2R,3S,4R,5R)-5-(6-amino-8-chloro-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)-(Sp)-phosphoryl)amino)propanoate in substantially diastereoisomerically pure form.
The compound of 14, wherein the compound of formula (I) is
- (2S)-Benzyl 2-(((((2R,3S,4R,5R)-5-(6-amino-8-chloro-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)-(Rp)-phosphoryl)amino)propanoate in substantially diastereoisomerically pure form.
The compound of 17, wherein the compound of formula (I) is benzyl 2-(((((2R,3S,4R,5R)-5-(6-amino-8-chloro-9H-purin-9-yl)-3,4-dihydroxytetra-hydrofuran-2-yl)methoxy)(phenoxy)-(Sp)-phosphoryl)amino)acetate in substantially diastereoisomerically pure form.
The compound of 17, wherein the compound of formula (I) is benzyl 2-(((((2R,3S,4R,5R)-5-(6-amino-8-chloro-9H-purin-9-yl)-3,4-dihydroxytetra-hydrofuran-2-yl)methoxy)(phenoxy)-(Rp)-phosphoryl)amino)acetate in substantially diastereoisomerically pure form.
20-24. (canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.