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US 2019/0375759 A1Published application
Pyrazole acc inhibitors and uses thereof
AssigneeGilead Apollo, LLC
InventorsShomir Ghosh, Jeremy Robert Greenwood, Geraldine C. Harriman, Silvana Marcel Leit de Moradei
Life of this patent
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Abstract
The present invention provides pyrazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Claims2
-26. (canceled)
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is —CH3, —CHCF2, or —CF3;
- R2 is
- R3 is
- R4 is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, tertiary butyl, —CH2CH2OH, —CH2CCH, —CH2CH2CCH, —CH2CHCH2, —CH2CHCH(CH3)2, —CH2CN, —CH2CH2CN, —CH2COCH3, —CH2— cyclopropyl, —CH2CH2SCH3, —CH2CH2OCH3, —CH2CH2COOCH3, —CH2COOCH3, —COOCH3, —CH2CH2SO2CH3, —CH2CONH2,
- X is H, F, Cl, Br, CN, CF3, methyl, ethyl, isopropyl, cyclopropyl, —SO2Me, —OCF2H, —CF2H, —OCF3, or —OCF2H;
- Y is optionally substituted alkyl, cyanomethyl, cyanoethyl, or methoxyethyl;
- T is independently H, F, Cl, or methyl;
- each A is independently H, CH3, CH2CH3, CHCF3, CH2CF2H, propyl, isopropyl, butyl, cyclopropyl, tertiary butyl, isobutyl, neopentyl, or cyanoethyl;
- and
- L1 is —CH(CH3), —C(CH3)2, or —CH2.
8 more elements
Dependencies are inferred from the claim text.