Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• z is an integer from 0 to 6;
• ring A is substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl;
• L1 and L2 are independently a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene;
• R1 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R2 is independently hydrogen, halogen, —CX23, —CHX22, —CH2X2, —OCX23, —OCHX22, —OCH2X2, —CN, —S(O)2R2A, —SR2A, —S(O)R2A, —SO2NR2AR2B, —NHC(O)NR2AR2B, —N(O)2, —NR2AR2B, NHNR2AR2B, —C(O)R2A, —C(O)—OR2A, —C(O)NR2AR2B, —C(O)NHNR2AR2B, —OR2A, —NR2ASO2R2B, —NR2AC(O)R2B, —NR2AC(O)OR2B, NR2AOR2B, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 is independently halogen, —CX33, —CHX32, —CH2X3, —OCX33, —OCHX32, —OCH2X3, —CN, —S(O)2R3A, —SR3A, —S(O)R3A, —SO2NR3AR3B, —NHC(O)NR3AR3B, —N(O)2, —NR3AR3B, —NHNR3AR3B, —C(O)R3A, —C(O)—OR3A, —C(O)NR3AR3B, —P(O)R3AR3B, —C(O)NHNR3AR3B, —OR3A, —NR3ASO2R3B, —NR3AC(O)R3B, —NR3AC(O)OR3B, —NR3AOR3B, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• two R3 may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R2A, R2B, R3A, and R3B are independently hydrogen, —F, —Cl, Br, —I, —CF3, —CHF2, —CH2F, —CCl3, —CHCl2, —CH2Cl, —CBr3, —CHBr2, —CH2Br, —CI3, —CHI2, —CH2I, —OCF3, —OCCl3, —OCBr3, —OCI3, —OCHF2, —OCHCl2, —OCHBr2, —OCHI2, —OCH2F, —OCH2Cl, —OCH2Br, —OCH2I, —N3, —CN, —SH, —SCH3, —SO2H, —SO2CH3, —SO2NH2, —SO2NHCH3, —NHC(O)NH2, —NHC(O)NHCH3, —NO2, —NH2, —NHCH3, —C(O)H, —C(O)CH3, —C(O)OH, —C(O)OCH3, —C(O)NH2, —C(O)NHCH3, —OH, —OCH3, —NHSO2H, —NHSO2CH3, —NHC(O)H, —NCH3C(O)H, —NHC(O)OH, —NCH3C(O)OH, —NHOH, —NCH3OH, —NCH3OCH3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R2A and R2B may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R3A and R3B may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• and
• X2 and X3 are independently halogen;
• with the proviso that when ring A is cyclohexyl, then R3 is not an ortho-substituted —NH2 or —HNC═(O)t-BuO, or para-substituted —NHSO2CH2CH2CF3, —NHSO2CH3, or —OH.