(hetero)arylamide compound for inhibiting protein kinase activity

A compound of formula (I), or a pharmaceutically acceptable salt, a stereoisomer, a solvate or a hydrate thereof:

• wherein:
• Y1 is selected from CRa or N;
• Y is independently selected from CRa or N;
• R1 is selected from hydrogen, halo, nitrile, nitro, C1-6 alkyl or C1-6 haloalkyl, wherein the said C1-6 alkyl or C1-6 haloalkyl is optionally substituted by R1a group;
• R2 is selected from hydrogen, C1-6 alkyl or C1-6 haloalkyl, wherein the said C1-6 alkyl or C1-6 haloalkyl is optionally substituted by R2a group;
• Z is a chemical bond, O, S(O)0-2 or NRb;
• or —Z—R2 together form —SF5;
• Ar is
• wherein X1 is S, X2 to X4 are independently selected from CR or N;
• and one of X2, X3 and X4 is C atom that connects the parent core;
• Het is
• wherein X9 is selected from O, S, NRb or C(R)2;
• m is 0, 1 or 2;
• n is 0, 1, 2, 3, 4, 5 or 6;
• Ra is independently selected from hydrogen, halo, nitrile, nitro, hydroxy, —NH2, —NHC1-6 alkyl, —N(C1-6 alkyl)2, C1-6 alkyl, C1-6 haloalkyl or C1-6 alkoxyl;
• Rb is independently selected from hydrogen, C1-6 alkyl or C1-6 haloalkyl;
• R1a, R2a and R are independently selected from hydrogen, halo, hydroxy, —NH2, —NHC1-6 alkyl, —N(C1-6 alkyl)2, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxyl, C3-7 cycloalkyl, C3-7 heterocyclyl, C6-10 aryl or C5-10 heteroaryl;
• or two R groups on the same or adjacent atoms may together form C3-7 cycloalkyl, C3-7 heterocyclyl, C6-10 aryl or C5-10 heteroaryl.