HDAC6 Selective Inhibitors, Preparation Method Therefor, and Application Thereof

A compound represented by formula (I), a pharmaceutically acceptable salt or a isomer thereof,

• is a single bond or a double bond;
• n is 0 or 1;
• each of T1, T2 is independently selected from the group consisting of CH, CH2, —C(═O)— and N;
• T3 is C or N;
• each of Z1, Z2, Z3 is independently CH or N;
• L1 is selected from the group consisting of a single bond, —NH— and —C(═O)—NH—;
• R1 is selected from the group consisting of C1-3 alkyl, phenyl or 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R;
• R2 is —H, F, Cl, Br or I;
• Ring A is 4 to 7-membered heterocycloalkyl;
• R is F, Cl, Br or I;
• the “hetero” in 6-membered heteroaryl or 4 to 7-membered heterocycloalkyl is independently —NH—, N or —O—;
• in any of the cases above, the number of heteroatom or heteroatom group is independently 1, 2 or 3, respectively.