Quinoline compound, preparation method and medical use therefor

A compound of general formula (I) or a pharmaceutically acceptable salt, solvate, metabolite or prodrug thereof,

• wherein:
• A is selected from the group consisting of NR4, S and O;
• W1 and W2 are each independently selected from the group consisting of N and CR3;
• R1 is selected from the group consisting of H and OR10;
• R10 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, —RuORx, —RuN(Ry)(Rz), —RuS(O)nN(Ry)(Rz) and —RuS(O)nRx;
• wherein the alkyl, alkenyl, alkynyl and cycloalkyl are each independently and optionally further substituted with one or more groups selected from the group consisting of halogen, cyano, hydroxyl, amino and alkyl;
• R2 is selected from the group consisting of Q groups and the following structures:
• R0 is identical or different and each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl and alkynyl, wherein the alkyl is optionally substituted with one or more alkoxy groups;
• R3 and R8 are each independently selected from the group consisting of halogens, —N(Ry)(Rz) and Q groups;
• R4 is selected from the group consisting of hydrogen, alkyl, alkoxy and cycloalkyl;
• R6 is selected from the group consisting of hydrogen, halogen, alkyl, haloalkyl, alkoxy, —ORuORx, —ORuN(Ry)(Rz) and —N(Ry)(Rz);
• R7 is selected from the group consisting of hydrogen, halogen, alkyl and cyano;
• R9 is selected from the group consisting of hydrogen, halogen, alkyl and haloalkyl;
• R5 is selected from the group consisting of hydrogen, alkyl, alkoxy and cycloalkyl;
• and G is selected from the group consisting of heteroaryl and heterocyclyl that are not thiazolyl or imidazolyl;
• wherein the heteroaryl and heterocyclyl are each independently and optionally substituted with one or more groups selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, amino, acyl, cycloalkyl, heterocyclyl, aryl, heteroaryl and
• wherein the alkyl, alkenyl, alkynyl, alkoxy, acyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each independently and optionally substituted with one or more groups selected from the group consisting of halogen, alkyl haloalkyl, alkenyl, alkynyl, aryl, hydroxyl, alkoxy, haloalkoxy, —N(Ry)(Rz), cycloalkyl, heterocyclyl, ester and cyano groups;
• or
• R5 and G are taken together with the nitrogen atom to which they are attached to form a heterocyclyl or heteroaryl group, wherein the heterocyclyl and heteroaryl are each independently and optionally substituted with one or more groups selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, amino, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl and heteroaryl are each independently and optionally substituted with one or more groups selected from the group consisting of halogen, alkyl, haloalkyl, alkenyl, alkynyl, aryl, hydroxyl, alkoxy, haloalkoxy, cycloalkyl, ester, and cyano;
• Ar is an aryl group optionally substituted with one or more R0;
• Het is a heterocyclyl group optionally substituted with one or more R0;
• Ru is selected from the group consisting of a bond, alkylene, alkenylene and alkynylene;
• Rx is selected from the group consisting of hydrogen, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, alkenyl and alkynyl;
• or
• —RuORx together form an oxygen-containing 3-7 membered heterocyclic ring, which is optionally substituted with one or more groups selected from the group consisting of halogen, haloalkyl, alkyl, aryl, alkenyl, and alkynyl;
• Ry and Rz are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, alkenyl, alkynyl, cycloalkyl, haloalkoxy and haloalkyl;
• or
• Ry and Rz are taken together with the nitrogen atom to which they are attached to form heterocyclyl or heteroaryl, wherein the heterocyclyl and heteroaryl are each independently and optionally substituted with one or more groups selected from the group consisting of halogen, haloalkyl, alkyl, aryl, acyl, alkenyl and alkynyl, wherein the alkyl is optionally substituted with one or more groups selected from the group consisting of alkoxy and cycloalkyl group;
• Q is selected from the group consisting of hydrogen, hydroxyl, alkyl, alkoxy, cycloalkyl, alkenyl, alkynyl, cyano, nitro, aryl, heterocyclyl and heteroaryl;
• wherein the alkyl, alkoxy, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl and heteroaryl are each independently and optionally substituted with one or more groups selected from the group consisting of hydroxyl, halogen and alkyl;
• n is 0, 1, or 2.