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US 2019/0375711 A1Published application
Pyridine based ionic fluoride for catalyzing indole and tetrazole formation
AssigneeKing Abdulaziz University
InventorsSarfaraz Ali GHUMRO, Rima D. Alharthy, Sana Saleem, Mariya Al-Rashida, Nafees Iqbal, Shakil Ahmed, Syed Abid Ali, Syed Tarique Moin, Abdul Hameed
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Abstract
A pyridine based ionic liquid with a fluoride counter anion which catalyzes Fischer indole reaction and click chemistry. Methods of preparing the ionic liquid, and methods of utilizing the ionic liquid as a catalyst to synthesize indoles/indolenines and tetrazoles are also provided.
Claims20
An ionic liquid of formula (I)
- or a solvate thereof, a tautomer thereof, a stereoisomer thereof, or a mixture thereof;
- wherein:
- R1 and R2 are independently selected from the group consisting of an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, and an optionally substituted aryl;
- R3 is selected from the group consisting of a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted alkoxy, an optionally substituted alkanoyl, an optionally substituted aroyl, a halogen, a nitro, and a cyano;
- R4 and R5 are independently selected from the group consisting of a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, and an optionally substituted aryl;
- and
- n is an integer in a range of 0-15.
4 more elements
Dependencies are inferred from the claim text.