Yap1 inhibitors that target the interaction of yap1 with oct4

A compound having Formula III

• wherein,
• X is C(O), S(O), or SO2;
• Y is CH, CR6, or N;
• Z is CH2, CR6R7, or NH;
• W is cyano, C2-C4 alkyne, or a triazole, tetrazole or oxaxole optionally substituted with one or more carbonyl (C═O), C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxyl, amino, —NR6R7, —C(O)NR6R7, C1-C6 alkylhydroxy, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, aryl, heteroaryl, halo, hydroxyl, thiol, cyano, nitro, or radiolabeled isotope;
• R1 is C1-C8 alkyl, C1-C8 alkenyl, C1-C8 alkynyl, C1-C8 alkoxyl, C1-C8 heteroalkyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, aryl, or heteroaryl, any of which is optionally substituted with one or more carbonyl (C═O), C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxyl, amino, —NR6R7, —C(O)NR6R7, C1-C6 alkylhydroxy, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, aryl, heteroaryl, halo, hydroxyl, thiol, cyano, nitro, or radiolabeled isotope;
• R2 is amino, hydroxyl, C1-C8 alkyl, C1-C8 alkenyl, C1-C8 alkynyl, C1-C8 alkoxyl, C1-C8 heteroalkyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, aryl, or heteroaryl, any of which is optionally substituted with one or more carbonyl (C═O), carboxyl (—CO2—), ester (CO2R6), C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxyl, amino, —NR6R7, —C(O)NR6R7, C1-C6 alkylC3-6 cycloalkyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, aryl, heteroaryl, C1-6alkylaryl, halo, hydroxyl, thiol, cyano, nitro, or radiolabeled isotope;
• each R3 is, independently, hydrogen, halogen, OH, C1-C8 alkyl, C1-C8 alkoxyl, aryl, O-aryl, heteroaryl, O-heteroaryl, O-CH2aryl, or O-CH2heteroaryl;
• and
• R6 and R7 are independently selected from hydrogen, C1-C8 alkyl, C1-C8 alkenyl, C1-C8 alkynyl, C1-C8 alkoxide, C1-C8 carboxylate, C1-C8 haloalkyl, C1-C8 haloalkenyl, C1-C8 haloalkynyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, aryl, C1-C3 alkylheteroaryl, or heteroaryl;
• any of which is optionally substituted with a halogen;
• and n is 1-5.