Tyramine containing hydroxycinnamic acid amide derivatives and methods of use thereof

A compound having the structure of Formula I, or an isomer, salt, homodimer, heterodimer, or conjugate thereof:

• wherein
• each occurrence of X is independently C or N;
• Z is —CR6— or —SO2—
• R1 is an —OH, —OCH2CH2R7, or —NHR8 group, or R1 together with R5 form a 6-membered substituted heterocycloalkyl ring,
• R2 and R3 are independently a hydrogen or —CH2CH2R7 group, or R2 and R3 together form a five- or six-membered heterocycloalkyl ring;
• R4 is a hydrogen or —CH2CH2R7 group;
• R5 is present or absent and when present is a substituent on one or more ring atoms and for each occurrence is independently a halo, hydroxy, alkyl, substituted alkyl, alkoxy, substituted sulfonyl, carboxyl ester, amino, substituted amino, cyano, aryl, substituted aryl, cycloalkyl, heteroaryl, substituted heteroaryl;
• R6 is H2, oxo, substituted alkyl, spirocycloalkyl or spiroheterocycloalkyl;
• R7 is a hydrogen, hydroxy, alkyl, substituted alkyl, alkoxy, substituted sulfonyl, carboxyl ester, amino, substituted amino, cyano, aryl, substituted aryl, cycloalkyl, heteroaryl, substituted heteroaryl;
• R8 is substituted sulfonyl, substituted alkyl, carboxyl ester or aminocarbonyl;
• and
• the dashed bond is present or absent.