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US 2019/0338313 A1Published application
Methods for making and using modified oocytes
AssigneeNew York Stem Cell Foundation, Inc.
InventorDietrich M. Egli
Life of this patent
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Abstract
The present invention provides modified oocytes having a nuclear genome derived from a first oocyte and cytoplasm derived from a second oocyte from a different subject, and methods for making and using such modified oocytes. The methods and compositions of the present invention can be useful in a variety of settings including, but not limited to, in in vitro fertilization (“IVF”) procedures.
Claims15
A method of treating infertility in a subject in need thereof, the method comprising using a modified oocyte in an assisted reproduction procedure, wherein the modified oocyte is produced by a method comprising:
- introducing a nuclear genome from a first oocyte from a subject that is infertile or has reduced or suboptimal fertility due to a defect in one or more cytoplasmic factor into an enucleated second oocyte not having the defect to form the modified oocyte, thereby treating infertility in a subject in need thereof.
Dependencies are inferred from the claim text.