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US 2019/0336611 A1Published application
Hybrid carriers for nucleic acid cargo
AssigneeCureVac AG
InventorsPatrick BAUMHOF, Carolin THIELE
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Abstract
The invention relates to carrier compositions for nucleic acid delivery which comprise a cationic peptide or polymer in combination with a cationic lipid. In a further aspect, the invention relates to nanoparticles comprising a complex of a bioactive cargo material with the peptide or polymer and the lipid. The invention further relates to the preparation and the uses of the nanoparticles.
Claims25
A composition comprising:
- (a) a cationic peptide or polymer;
- (b) a cationic lipid;
- and
- (c) a nucleic acid compound;
- wherein the cationic peptide or polymer is not a cationic compound comprising a cationic moiety P having at least one —SH group capable of forming a disulfide linkage, or a disulfide-linked multimer thereof, and wherein moiety P is selected from a polymer moiety having a molecular weight from about 0.5 kDa to about 30 kDa or from a peptide moiety composed of 3 to 100 amino acids wherein at least 10% of the total number of amino acids of the peptide moiety represent basic amino acids selected from Arg, Lys, His and/or Orn.
2 more elements
(canceled)
18-21. (canceled)
A nanoparticle obtainable by a method comprising a step of combining
- (i) one or more cationic peptides and/or polymers;
- (ii) one or more cationic lipids;
- and
- (iii) one or more nucleic acid compounds
- in the presence of an aqueous liquid such as to allow the formation of a nanoparticle.
2 more elements
24-25. (canceled)
27-29. (canceled)
31-32. (canceled)
Dependencies are inferred from the claim text.