Method for identifying inhibitors of primary nucleation of amyloid-beta aggregation
AssigneeForschungszentrum Juelich GmbH
InventorWolfgang Hoyer
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Abstract
A method for identifying inhibitors of the primary nucleation of amyloid beta aggregation includes providing an A-beta species in solution or in a buffer, and determining the amyloid-beta aggregation, wherein the A-beta species comprises two A-beta monomer units with a linker arranged between the A-beta monomer units is provided. A method for analyzing aggregation of monomers of protein misfolding diseases and a kit are also provided.
Claims22
A method for identifying inhibitors of the primary nucleation of amyloid beta aggregation comprising:
- providing an A-beta species in solution or in a buffer;
- and
- determining a level of amyloid-beta aggregation;
- wherein the A-beta species comprises two A-beta monomer units with a linker arranged between the A-beta monomers.
A method for analyzing aggregation of monomers of protein misfolding diseases comprising:
- providing a monomer species of the protein misfolding disease in solution or in a buffer;
- and
- determining a level of aggregation of the monomer species;
- wherein
- the monomer species comprises two units of a monomer occurring in the protein misfolding disease with a linker arranged between the monomer units.
Dependencies are inferred from the claim text.