US 2019/0317074 A1 · APPARATUS AND METHOD FOR THE DETERMINATION OF SEPSIS RISK USING COMPONENTS OF EXHALED BREATH

Abstract

Disclosed herein are methods and devices for measurement of carbon dioxide and nitric oxide in exhaled breath of patients at risk for or suffering from sepsis. Carbon dioxide and nitric oxide levels may be measured in controlled rate breath and/or end tidal breath, and a risk score for the patient developing or having sepsis may be determined. In many embodiments, carbon dioxide and nitric oxide measurements are determined simultaneously in a single breath, and by a single measurement apparatus, while other embodiments measure nitric oxide and carbon dioxide levels using separate measure apparatuses and/or in different breaths of the patient.

Claims19

Dependent claims

A sepsis assessment device comprising:

a fluid input in fluid communication with a respiratory tract of a patient, wherein the fluid input receives an exhaled breath from the patient;
a NO measurement device that determines a NO concentration in the exhaled breath;
a CO2 measurement device that determines a CO2 concentration in the exhaled breath;
an input/output interface;
a processing element in electrical communication with the CO2 and NO measurement devices and the input/output interface, wherein the processing element receives a first signal corresponding to the NO concentration;
receives a second signal corresponding to the CO2 concentration;
determines a sepsis risk score based on the first signal and the second signal;
and
transmits the sepsis risk score to the input/output interface.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/381,960Filed 11 Apr 2019

Priority

13 Apr 2018

Published

17 Oct 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

G01N 33/497
Physical analysis of biological material: of gaseous biological material, e.g. breath
A61B 5/082
Measuring devices for evaluating the respiratory organs: evaluation by breath analysis, e.g. determination of the chemical composition of exhaled…
A61B 5/412
Detecting, measuring or recording for evaluating the immune or lymphatic systems: detecting or monitoring sepsis
G01N 33/0037
Specially adapted to detect a particular component: nox

Apparatus and method for the determination of sepsis risk using components of exhaled breath

Life of this patent

Apparatus and method for the determination of sepsis risk using components of exhaled breath

Life of this patent

Abstract

Claims19