US 2019/0317045 A1Published application

Method and apparatus to characterize pressurized liquid sample

AssigneeWyatt Technology Corporation

InventorHung-Te Hsieh

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Abstract

A method and apparatus for measuring the physical properties of a drug formulation suspended in a pressurized liquid propellant and a system to enable such measurements is disclosed. Drug formulations suspended in pressurized liquid propellant used in Pressurized Metered Dose Inhalers (pMDIs) are propelled in their native liquid state into an analytical instrument with a measurement cell capable of withstanding the pressure required to retain the sample in liquid form by employing a device to rapidly release the contents of the pMDI canister into the measurement instrument wherein the sample's electrophoretic mobility and size may be determined by MP-PALS or other techniques. A series of valves permits the maintenance of the high pressure in the system. Once the measurements are made, the pressurized liquid is allowed to pass to waste or another analytical instrument by opening an exit valve.

Claims13

Dependent claims

An apparatus comprising:

an inlet valve;
inlet tubing connecting the inlet valve to a measurement cell,
wherein the inlet valve is located upstream of the measurement cell;
an outlet valve,
wherein the outlet valve is located downstream of the measurement cell;
outlet tubing connecting the measurement cell to the outlet valve;
and a rapid release adapter,
wherein an outlet of the rapid release adapter is connected to an inlet port of the inlet valve,
wherein an inlet port of the rapid release adapter is configured to be connected to a canister containing a liquid sample maintained in a liquid state by a pressure in the canister, and
wherein the rapid release adapter is configured to release the liquid sample from the canister into the inlet valve and the inlet tubing, thereby releasing the liquid sample into the measurement cell;
and
wherein the measurement cell is configured to measure physical properties of the liquid sample in the measurement cell,
wherein the liquid sample is maintained in a liquid state while the measurement cell measures the physical properties.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/451,949Filed 25 Jun 2019
Priority: 16 Jan 2017
Published: 17 Oct 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

G01N 27/44721
Arrangements for investigating the separated zones, e.g. localising zones: by optical means
G01N 15/00
Investigating characteristics of particles
G01N 21/53
Within a body or fluid: within a flowing fluid, e.g. smoke
G01N 33/15
Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00: medicinal preparations ; Physical properties…

Family

Application15/407,157Continuation · filed 16 Jan 2017
Application16/451,949Continuation
US 10,330,638 B2Related patent
US 10,837,942 B2Related patent
US 2018/0202967 A1Published application
US 2019/0317045 A1This patent

From the US filing history. Foreign family members aren’t listed.

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