Predictive biomarkers for cancer immunotherapy and methods of using same
AssigneeDuke University
InventorsBrent Hanks, Nicholas Devito, Balamayooran Theivanthiran, Fei Zhao
Life of this patent
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Abstract
The present disclosure provides methods of detecting a wnt-β-catenin-mediated cancer and an immunotherapy resistant cancer by detecting the presence of an associated biomarker. Further, methods of threating the wnt-β-catenin-mediated cancer or immunotherapy resistant cancer are provided.
Claims21
A method of detecting the presence of a wnt-β-catenin-mediated cancer in a subject comprising detecting in a biological sample derived from the subject at least one biomarker associated with wnt-β-catenin-mediated cancer selected from the group consisting of wnt5a, CXCL2, CXCL5, CXCR2, HSP70, S100A8, S100A9, YAP1, NPRP3 and combinations thereof.
A method of determining the presence of an immunotherapy-resistant wnt-β-catenin-mediated cancer in a subject comprising detecting at least one biomarker selected from the group consisting of wnt5a, CXCL2, CXCL5, CXCR2, HSP70 and combinations thereof present in a biological sample derived from the subject, wherein the biomarker is associated with an immunotherapy-resistant wnt-β-catenin-mediated cancer.
A method of treating a subject having or suspected of having an immunotherapy resistant tumor, the method comprising:
- (a) detecting the presence of a wnt-β-catenin-mediated cancer in a subject comprising detecting in a biological sample derived from the subject at least one biomarker associated with wnt-β-catenin-mediated cancer selected from the group consisting of wnt5a, CXCL2, CXCL5, CXCR2, HSP70, S100A8, S100A9, YAP1, NPRP3 and combinations thereof, wherein detection of the one or more biomarkers indicated an immunotherapy resistant tumor, and
- (b) administering a therapeutically effective amount of one or more anti-wnt-β-catenin-mediated cancer immunotherapy to the subject having an immunotherapy resistant tumor.
Dependencies are inferred from the claim text.