Mir-320e and colorectal cancer
AssigneeBaylor Research Institute
InventorsAjay Goel, Lucia Perez-Carbonell, C. Richard Boland
Life of this patent
Estimating the term…
Abstract
Embodiments provide methods and compositions related to determining treatments for colorectal cancer patients by detection and analysis of the expression level of miRNA such as miR-320e in the patients.
Claims22
1-40. (canceled)
A method for treating a patient with colorectal cancer comprising administering a treatment to the patient that inhibits the expression of miR-320e, wherein a sample from the patient is determined to have an increased expression level in a gene encoding miR-320e compared to a control or reference expression level for the gene.
42-51. (canceled)
A method of detecting the expression level of miR-320e in a human subject diagnosed with colorectal cancer and selecting a treatment for a human subject diagnosed with colorectal cancer, the method comprising:
- a.) assaying nucleic acids obtained from a biological sample from the human subject to determine a first expression level of miR-320e in the biological sample from the human subject;
- and
- b.) comparing the first expression level of miR-320e in the biological sample from the human subject to a reference expression level of miR-320e indicative of recurrent colorectal cancer;
- or
- comparing the first expression level of miR-320e in the biological sample from the human subject to a reference expression level of miR-320e indicative of non-recurrent colorectal cancer.
Dependencies are inferred from the claim text.