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AssigneesNational Cancer Center, BIOMIMETICS SYMPATHIES. Inc
InventorsTakahiro Ochiya, Akira Yokoi, Tomoyasu Kato
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[Problem] To provide: a marker and a kit both for use in the prediction of ovarian cancer prognosis; and a prognosis prediction method. [Solution] A marker and a kit, both for use in the prediction of ovarian cancer prognosis, each of said marker and kit containing a transcript of matrix metalloprotease (MMP) 1 gene; and a method for predicting ovarian cancer prognosis using the marker or the kit, in which the expression level of matrix metalloprotease (MMP) 1 gene in a biological sample collected from a subject is by detecting an ovarian cancer prognosis prediction marker comprising a transcript of matrix metalloprotease (MMP) 1 gene and then obtaining a detection value of the ovarian cancer prognosis prediction marker.
1, A method for predicting the prognosis of ovarian cancer, comprising obtaining a detection value of a transcription product of full-length matrix metalloprotease (MMP) 1 gene in ascites collected from a subject or exosomes recovered from ascites, and measuring the expression level of the full-length matrix metalloprotease (MMP) 1 gene.
2, The method of claim 1, further comprising the step of comparing the detection value of the transcription product of the full-length matrix metalloprotease (MMP) 1 gene with a detection value of a transcription product of the internal standard gene in the ascites collected from the subject or the exosomes recovered from the ascites, and determining that the detection value of the transcription product of the full-length matrix metalloprotease (MMP) 1 gene is positive when the ratio of the detection value of the transcription product of the full-length matrix metalloprotease (MMP) 1 gene to the detection value of the transcription product of the internal standard gene in the ascites or the exosomes recovered from the ascites is a predetermined ratio or more.