Methods for Treating and Detecting Johne's Disease in Cattle
AssigneeCNA Diagnostics Inc.
InventorsChristoph W. Sensen, Jung Soh, Petra Heidinger, Laura Villanova, Stefan Grabuschnig
Life of this patent
Estimating the term…
Abstract
Biomarkers for identifying Johne's disease in cattle are presented herein, as are related methods, uses, agents, and kits comprising same. Methods for treating, detecting, quarantining, and diagnosing Johne's disease in cattle are presented herein.
Claims20
A method for treating a bovine animal suspected of having Johne's disease, the method comprising treating the bovine animal identified as having Johne's disease with a therapeutically effective amount of at least one agent used to treat Johne's disease, wherein the bovine animal is identifiable as having Johne's disease by
- analyzing a biological sample isolated from the bovine animal for over-representation or under-representation of at least one polynucleotide relative to an internal standard region, wherein the at least one polynucleotide comprises any one of SEQ ID NOs:
- 1-16 or 134-164 and wherein the over-representation or under-representation of the at least one polynucleotide in the biological sample is a positive indicator of Johne's disease.
A probe comprising a manmade nucleotide sequence capable of binding specifically to a polynucleotide comprising any one of SEQ ID NOs:
- 1-16 or 134-164 and at least one manmade tag conjugated thereto, wherein the manmade nucleotide sequence is complementary to the polynucleotide comprising any one of SEQ ID NOs:
- 1-16 or 134-164.
An array comprising at least one probe comprising a manmade nucleotide sequence capable of binding specifically to a polynucleotide comprising any one of SEQ ID NOs:
- 1-16 or 134-164, wherein the manmade nucleotide sequence is complementary to the polynucleotide comprising any one of SEQ ID NOs:
- 1-16 or 134-164, wherein the at least one probe is bound to a solid surface.
Dependencies are inferred from the claim text.