Insecticidal Proteins
AssigneeSyngenta Participations AG
InventorsClarence Michael REYNOLDS, Christopher FLEMING, Mark Greer MONTGOMERY
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Abstract
Compositions and methods for controlling plant pests are disclosed. In particular, novel insecticidal proteins having toxicity against Coleopteran and/or Lepidopteran insect pests are provided. Nucleic acid molecules encoding the novel insecticidal proteins are also provided. Methods of making the insecticidal proteins and methods of using the insecticidal proteins and nucleic acids encoding the insecticidal proteins of the invention, for example in transgenic plants to confer protection from insect damage, are also disclosed.
Claims26
An expression cassette comprising a promoter operably linked to a heterologous nucleic acid molecule comprising:
- (a) a nucleotide sequence of any one of SEQ ID NOs:
- 2 to 36, SEQ ID NO:
- 73 to 83, or SEQ ID NO:
- 99;
- (b) a nucleotide sequence that is at least 45% identical to the nucleotide sequence of any one of SEQ ID NOs:
- 2 to 36, SEQ ID NO:
- 73 to 83, or SEQ ID NO:
- 99;
- (c) a nucleotide sequence that encodes a polypeptide, wherein the amino acid sequence of the polypeptide comprises SEQ ID NO:
- 1, SEQ ID NO:
- 37 to 72, SEQ ID NO:
- 86 to 96, or SEQ ID NO:
- 100;
- (d) a nucleotide sequence that encodes a polypeptide, wherein the amino acid sequence of the polypeptide is at least 45% similar to the amino acid sequence of SEQ ID NO:
- 1, SEQ ID NO:
- 37 to 72, SEQ ID NO:
- 86 to 96, or SEQ ID NO:
- 100;
- or
- (e) a nucleotide sequence that is complementary to the nucleotide sequence of any one of (a) to (d) above.
A nucleic acid molecule comprising a nucleic acid sequence of any one of SEQ ID NOs:
- 2, SEQ ID NO:
- 4 to 36, SEQ ID NO:
- 73 to 83, or SEQ ID NO:
- 99.
(canceled)
-16. (canceled)
(canceled)
-23. (canceled)
25-31. (canceled)
-38. (canceled)
-42. (canceled)
A polypeptide comprising a) an amino acid sequence of any one of SEQ ID NO:
- 37 to 69 or SEQ ID NO:
- 86-96;
- or b) an amino acid sequence at least 45% identical to any one of SEQ ID NOs:
- 1, SEQ ID NO:
- 37 to 69, SEQ ID NO:
- 72, SEQ ID NO:
- 86-96, or SEQ ID NO:
- 100, and further comprising a mutation that introduces a protease cleavage site.
(canceled)
-58. (canceled)
Dependencies are inferred from the claim text.