Anti-Fibrinogen Aptamers and Uses Thereof

An aptamer capable of specifically binding to fibrinogen, wherein:

• the aptamer comprises a polynucleotide having at least 70% of sequence identity with the nucleotide sequence of SEQ ID No 66, or
• the aptamer comprises the nucleotide moiety of formula (II):
• 5′-[SEQ ID NO:
• 79]-[X1]SEQ ID NO:
• 77]-[X2]- [SEQ
• ID NO:
• 78]-3′ (III)
• wherein:
• [X2] and [X1] are independently a nucleotide or an oligonucleotide of 2 to 5 nucleotides in length,
• [SEQ ID NO:77] is an oligonucleotide of SEQ ID NO:77 (namely GTTGGTAGGG),
• [SEQ ID NO:78] is an oligonucleotide of SEQ ID NO:78 (namely GGTGTAT), and
• [SEQ ID NO:79] is an oligonucleotide of SEQ ID NO:79 (namely TGT).