Composition comprising a gene vector that selectively depletes p16 positive senescent cells
AssigneesUnity Biotechnology, Inc., Kythera Biopharmaceuticals, Inc.
InventorsSerge Lichtsteiner, Nathaniel David
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Abstract
Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for inducing apoptosis in a senescent cell comprising administering to the cell a polynucleotide, virus, host cell, or pharmaceutical composition described herein. Other methods include expressing a pro-apoptotic gene in a senescent cell comprising administering to the cell the polynucleotide, virus, or pharmaceutical composition as described herein.
Claims10
A composition comprising a conditionally replicating virus in a pharmaceutically compatible excipient, wherein the conditionally replicating virus has a recombinant genome construct in which a replication gene for the virus is placed under transcriptional control of a heterologous promoter,
- wherein the heterologous promoter is the p16 promoter,
- wherein when the conditionally replicating virus is applied to a mixed cell population comprising target cells that express p16, the p16 promoter causes the virus to replicate preferentially in the target cells, thereby causing lysis of the target cells and selectively depleting them from the cell population.
Dependencies are inferred from the claim text.